Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1991-06-12
1992-04-21
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
4351723, 435212, 4352402, 43525233, 4352523, 435255, 4353201, 536 27, 935 14, 935 28, 935 29, 935 32, 935 69, 935 70, 935 73, C12N 964, C12N 1558
Patent
active
051067412
ABSTRACT:
This invention discloses human tissue plasminogen activator (TPA) analogs. The analogs are TPA-like molecules that have had the native domain regions either rearranged, delected, added or a combination thereof. The analogs are the product of the expression of recombinant DNA also described herein. Additonally, the present invention described replication and expression plasmids containing the TPA-coding DNA sequences described above and suitable host microorganisms that are capable of expressing the TPA analogs after becoming transformed with an appropriate plasmid.
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Marotti Keith R.
Rehberg Edward F.
Theriault Nicole Y.
DeLuca Mark
Schwartz Richard A.
The Upjohn Company
Treptow Nancy
Wright Debbie K.
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