Process for the preparation of Chlorambucil derivatives

Details Process for the preparation of Chlorambucil derivatives Process for the preparation of Chlorambucil derivatives

1979-08-01

1981-04-14

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424238, 2603974, C07J 100, A61K 3156

Patent

active

042619106

ABSTRACT:
The Chlorambucil derivatives are novel compounds having the formula (I). ##STR1## wherein R represents a hydrogen atom or an acyl group such as ##STR2## and n is 1 or 2. The Chlorambucil derivatives can be produced by binding Chlorambucil to hydroxyl group at 17-position of estradiol or its derivative in the presence of a binding agent selected from the group consisting of compounds having the formula

REFERENCES:
patent: 3963707 (1976-06-01), Hogberg et al.
patent: 4029778 (1977-06-01), Fex et al.
patent: 4150126 (1979-04-01), Fex et al.
patent: 4180504 (1979-12-01), Hansen et al.
patent: 4181669 (1980-01-01), Hansen et al.

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