Process for the preparation of optionally substituted 2,3-indoli

Details Process for the preparation of optionally substituted 2,3-indoli Process for the preparation of optionally substituted 2,3-indoli

1979-12-26

1981-04-14

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D20940

Patent

active

042618940

ABSTRACT:
An improved process for the preparation of optionally substituted 2,3-indolinediones which are useful as intermediates in the preparation of compounds having pharmacological activity which comprises reacting a 3,1-benzoxazine with an alkali or alkaline earth metal cyanide or a tetra-(C.sub.1-4) alkylammonium cyanide to obtain a 2-imino-3-indolinone, which is then subjected to hydrolysis.

REFERENCES:
patent: 3132151 (1964-05-01), Bortnick et al.
patent: 3984563 (1976-10-01), Winters et al.
S. Kadin et al., Chem. Abstracts 87:151986y (1977), A Convenient Synthesis of 2-amino-4-hydroxyquinolines.
H. Aurich et al., Chem. Ber. 1972, 105(7), 2389-2397.

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