Stable dithranol compositions in anhydrous vehicles

Details Stable dithranol compositions in anhydrous vehicles Stable dithranol compositions in anhydrous vehicles

1981-05-13

1983-01-04

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Binds hapten, hapten-carrier complex, or...

424240, 424346, 424365, A61K 3100, A61K 3105, A61K 4700

Patent

active

043672248

ABSTRACT:
Stable dithranol compositions in anhydrous vehicles therapeutically effective as topical treatment for skin disorders such as psoriasis, eczema and seborrheic dermatitides are disclosed. Incorporation of oxalic acid in anhydrous dithranol compositions has been found to chemically stabilize said dithranol. Oxalic acid may be present in an amount of from 0.01-to-2 percent by weight of the total composition. The anhydrous vehicle includes an anhydrous base formulated from glyceryl monostearate and isopropyl myristate or isopropyl palmitate as major ingredients.

REFERENCES:
patent: 4287214 (1981-09-01), Van Scott et al.
Chemical Abstracts 78:75809q (1973).
Chemical Abstracts 67:2878z (1967).
Sagarin-Cosmetics, Science & Technology, 1957, pp. 1066-1067.

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