Process for preparing thiophene derivatives

Details Process for preparing thiophene derivatives Process for preparing thiophene derivatives

1988-06-13

1989-12-26

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D33328

Patent

active

048899402

ABSTRACT:
A process for the preparation of a thiophene derivative which is substituted at the beta-position by a bromine atom, which comprises reacting the corresponding beta-unsubstituted thiophene with an aromatic compound which is substituted with a bromine atom, in the presence of an alkali metal amide and a catalyst which is capable of forming a complex with the cation of the alkali metal amide.

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Reinecke, M. G., et al. J. Org. Chem., vol. 36, No. 18, 2690-2692 (1971).
Soula, G., J. Org. Chem. 50, 3717-3721 (1985).
TDA-1 Catalog, Rhone-Poulenc Division Specialites Chimiques, Doc. (1) 47 88 17 15.
Van der Plas, H. C., et al., Recueil 93, 33-36 (1974).
Dettmeier, U., et al., Angew. Chem. Int. Ed. Engl. 26 (1987), No. 5, p. 468.
Gronowitz, S., Heterocyclic Chemistry, Thiophene and its Derivatives, vol. 44, part 2, p. 243.
Organic Synthesis, vol. 44, pp. 9-11.

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