Plastic and nonmetallic article shaping or treating: processes – Encapsulating normally liquid material – Liquid encapsulation utilizing an emulsion or dispersion to...
Patent
1995-06-07
1997-08-12
Nutter, Nathan M.
Plastic and nonmetallic article shaping or treating: processes
Encapsulating normally liquid material
Liquid encapsulation utilizing an emulsion or dispersion to...
264 43, 424489, 424490, 424491, 424501, B01J 1302, B01J 1304, B01J 1320, B01J 1322
Patent
active
056562110
ABSTRACT:
A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3.degree.. The total length of travel around the figure-8 pattern is at least 0.7 cm.
REFERENCES:
patent: 3532500 (1970-10-01), Priest et al.
patent: 3873564 (1975-03-01), Schneider et al.
patent: 4089801 (1978-05-01), Schneider
patent: 4162282 (1979-07-01), Fulwyler et al.
patent: 4192859 (1980-03-01), Mackaness et al.
patent: 4224179 (1980-09-01), Schneider
patent: 4229360 (1980-10-01), Schneider et al.
patent: 4276885 (1981-07-01), Tickner et al.
patent: 4310505 (1982-01-01), Baldeschwieler et al.
patent: 4310506 (1982-01-01), Baldeschwieler et al.
patent: 4315514 (1982-02-01), Drewes et al.
patent: 4331654 (1982-05-01), Morris
patent: 4344929 (1982-08-01), Bonsen et al.
patent: 4426330 (1984-01-01), Sears
patent: 4428924 (1984-01-01), Millington
patent: 4442843 (1984-04-01), Rasor et al.
patent: 4466442 (1984-08-01), Hilmann et al.
patent: 4533254 (1985-08-01), Cook et al.
patent: 4534899 (1985-08-01), Sears
patent: 4544545 (1985-10-01), Ryan et al.
patent: 4569836 (1986-02-01), Gordon
patent: 4572203 (1986-02-01), Feinstein
patent: 4586512 (1986-05-01), Du-huu et al.
patent: 4603044 (1986-07-01), Geho et al.
patent: 4615879 (1986-10-01), Runge et al.
patent: 4620546 (1986-11-01), Aida et al.
patent: 4646756 (1987-03-01), Watmough et al.
patent: 4657756 (1987-04-01), Rasor et al.
patent: 4658828 (1987-04-01), Dory
patent: 4675310 (1987-06-01), Chapman et al.
patent: 4681119 (1987-07-01), Rasor et al.
patent: 4684479 (1987-08-01), D'Arrigo
patent: 4689986 (1987-09-01), Carson et al.
patent: 4718433 (1988-01-01), Feinstein
patent: 4728575 (1988-03-01), Gamble et al.
patent: 4728578 (1988-03-01), Higgins et al.
patent: 4731239 (1988-03-01), Gordon
patent: 4737323 (1988-04-01), Martin et al.
patent: 4774958 (1988-10-01), Feinstein
patent: 4775522 (1988-10-01), Clark, Jr.
patent: 4776991 (1988-10-01), Farmer et al.
patent: 4781871 (1988-11-01), West, III et al.
patent: 4790891 (1988-12-01), Halliday et al.
patent: 4830858 (1989-05-01), Payne et al.
patent: 4844882 (1989-07-01), Widder et al.
patent: 4863717 (1989-09-01), Keana
patent: 4865836 (1989-09-01), Long, Jr.
patent: 4877561 (1989-10-01), Iga et al.
patent: 4893624 (1990-01-01), Lele
patent: 4895719 (1990-01-01), Radhakrishnan
patent: 4898734 (1990-02-01), Mathiowitz et al.
patent: 4900540 (1990-02-01), Ryan et al.
patent: 4921706 (1990-05-01), Roberts et al.
patent: 4927623 (1990-05-01), Long, Jr.
patent: 4938947 (1990-07-01), Nicolau et al.
patent: 4957656 (1990-09-01), Cerny et al.
patent: 4981692 (1991-01-01), Popescu et al.
patent: 4987154 (1991-01-01), Long, Jr.
patent: 4996041 (1991-02-01), Arai et al.
patent: 5000960 (1991-03-01), Wallach
patent: 5008050 (1991-04-01), Cullis et al.
patent: 5013556 (1991-05-01), Woodle et al.
patent: 5045304 (1991-09-01), Schneider et al.
patent: 5049388 (1991-09-01), Knight et al.
patent: 5088499 (1992-02-01), Unger
patent: 5114703 (1992-05-01), Wolf et al.
patent: 5123414 (1992-06-01), Unger
patent: 5137928 (1992-08-01), Erbel et al.
patent: 5141738 (1992-08-01), Rasor et al.
patent: 5147631 (1992-09-01), Glajch et al.
patent: 5149319 (1992-09-01), Unger
patent: 5171755 (1992-12-01), Kaufman
patent: 5186922 (1993-02-01), Shell et al.
patent: 5190982 (1993-03-01), Erbel et al.
patent: 5194266 (1993-03-01), Abra et al.
patent: 5195520 (1993-03-01), Schlief et al.
patent: 5196183 (1993-03-01), Yudelson et al.
patent: 5198225 (1993-03-01), Meybeck et al.
patent: 5205287 (1993-04-01), Erbel et al.
patent: 5209720 (1993-05-01), Unger
patent: 5213804 (1993-05-01), Martin et al.
patent: 5215680 (1993-06-01), D'Arrigo
patent: 5219538 (1993-06-01), Henderson et al.
patent: 5228446 (1993-07-01), Unger et al.
patent: 5230882 (1993-07-01), Unger
patent: 5271928 (1993-12-01), Schneider et al.
patent: 5305757 (1994-04-01), Unger et al.
patent: 5310540 (1994-05-01), Giddey et al.
patent: 5315997 (1994-05-01), Widder et al.
patent: 5316771 (1994-05-01), Barenholz et al.
patent: 5334381 (1994-08-01), Unger
patent: 5344930 (1994-09-01), Riess et al.
patent: 5350571 (1994-09-01), Kaufman et al.
patent: 5352435 (1994-10-01), Unger
patent: 5380519 (1995-01-01), Schneider et al.
patent: 5393524 (1995-02-01), Quay
patent: 5409688 (1995-04-01), Quay
patent: 5410516 (1995-04-01), Uhlendorf et al.
patent: 5413774 (1995-05-01), Schneider et al.
patent: 5425366 (1995-06-01), Reinhardt et al.
patent: 5433204 (1995-07-01), Olson
patent: 5445813 (1995-08-01), Schneider et al.
patent: 5469854 (1995-11-01), Unger et al.
patent: 5470582 (1995-11-01), Supersaxo et al.
patent: 5487390 (1996-01-01), Cohen et al.
patent: 5496535 (1996-03-01), Kirkland
patent: 5505932 (1996-04-01), Grinstaff et al.
patent: 5529766 (1996-06-01), Klaveness et al.
patent: 5531980 (1996-07-01), Schneider et al.
patent: 5536489 (1996-07-01), Lohrmann et al.
patent: 5536490 (1996-07-01), Klaveness et al.
patent: 5540909 (1996-07-01), Schutt
patent: B14229360 (1991-11-01), Schneider et al.
Frezard, et al., "Permeability and stability in buffer and in human serum of fluorinated phospholipid-based liposomes", Biochimica et Biophysica Acta, 1192, pp. 61-70 (1994).
Frezard, et al., "Fluorinated Phospholipid-Based Vesicles as Potential Drug Carriers: Encapsulation/Sustaining of Drugs and Stability in Human Serum", Art, Cells, Blood Subs., and Immob. Biotech., 22(4), pp. 1403-1408 (1994).
Kost et al., Polymers in Medicine II: Biomedical and Pharmaceutical Applications, "Ultrasonic Modulated Drug Delivery Systems", Chiellini et al., ed., (Plenum Press, New York and London), pp. 387-396 (1985).
Moseley et al., Microbubbles: A Novel MR Susceptibility Contrast Agent, abstract, 1991 Napa, California Meeting of the Society for Magnetic Resonance in Medicine.
Ter-Pogossian, M., "Physical Principles and Instrumentation", Computed Body Tomography, Kee et al., eds., Raven Press, New York, Chapter 1, pp. 1-7, 2nd Edition, 1988.
Aronberg, D.J., "Techniques" Computed Body Tomography, Kee et al., eds., Raven Press, New York, Chapter 2, pp. 9-36, 2nd Edition, 1988.
Dittrich, "Cardiac Muscle Ischemia and Infarction", The Second Annual Int. Symposium on Contrast Agents and Diagnostic Ultrasound, Atlantic City, NJ (May 7, 1996) (Abstract).
Pantely, "Intravenous Contrast Echocardiography-Tissue Imaging & Quantification of Coronary Blood Flow", The Second Annual Int. Symposium on Contrast Agents in Diagnostic Ultrasound, Atlantic City, NJ (May 7, 1996) (Abstract).
Shiina et al., "Hyperthermiaby Low-frequency Synthesized Ultrasound", IEEE Engineering, pp. 879-880, vol. 2 (abstract) (1988).
Miller, D.L., "Ultrasonic Detection of Resonant Cavitation Bubbles in a Flow Tube by Their Second-Harmonic Emissions", Ultrasonics, Sep. 1981, 217-224.
Fitzpatrick, et al., "Metal Ion Catalyzed Decarboxylation: Kinetics and Mechanism of the Oxidative Decarboxylation of Copper (II) Complexes of Aminomalonic Acid in Aqueous Solution", Inorganic Chemistry, vol. 13, No. 3, pp. 568-574 (1974).
Thanassi, 37 Aminomalonic Acid: Spontaneous Decarboxylation and Reaction with 5-Deoxypyridoxal", Biochemistry, vol. 9, No. 3, pp. 525-532 (1970).
Stelmashok et al., Koordinatsionnaya Khimiya, vol. 3, No. 4, pp. 524-527 (1977) (Russian and English language versions).
Mayhew et al., "High-Pressure Continuous-Flow System for Drug Entrapment in Liposomes", Methods in Enzymology, vol. 149, pp. 64-77 (1987).
Mayhew et al., "Characterization of Liposomes Prepared Using a Microemulsifier", Biochimica et Biophysica Acta, vol. 775, pp.
Barrette Terrence R.
McCreery Thomas
Unger Evan
Yellowhair David
ImaRx Pharmaceutical Corp.
Nutter Nathan M.
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