Substituted imidazo[1,5-a]pyridine derivatives and other substit

Details Substituted imidazo[1,5-a]pyridine derivatives and other substit Substituted imidazo[1,5-a]pyridine derivatives and other substit

1987-11-13

1989-12-26

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142282, 5142332, 514252, 544 61, 544127, 544362, 546121, A61K 31395, A61K 31495, C07D47104, C07D41700

Patent

active

048898619

ABSTRACT:
Disclosed are compounds of formula I ##STR1## wherein R.sub.1 represents hydrogen, lower alkyl, substituted lower alkyl, nitro, halogen, free, etherified or esterified hydroxy, free, etherified, oxidized etherified or esterified mercapto, unsubstituted, mono- or disubstituted amino, ammonio, free or functionally modified sulfo, free or functionally modified formyl, C.sub.2 --C.sub.20 -acyl, cyano, free or functionally modified carboxy; and R.sub.2 represents hydrogen, lower alkyl, substituted lower alkyl, halogen; free, etherified or esterified hydroxy; free, etherified, oxidized etherified or esterified mercapto; free or functionally modified carboxy, or acyl; the 7,8-dihydro derivatives thereof; and compounds of the formula I* ##STR2## wherein n denotes 0, 1, 2, 3 or 4, and R.sub.1 and R.sub.2 are as defined above under formula I and salts thereof; e.g. as aromatase inhibitors; pharmaceutical compositions containing these compounds; the use of these compounds for the treatment of conditions responsive to e.g. aromatase inhibition in mammals; processes and intermediates for preparing these compounds.

REFERENCES:
patent: 4409226 (1983-10-01), Bristol et al.
patent: 4444775 (1984-04-01), Ford
patent: 4588732 (1986-05-01), Browne
patent: 4602025 (1986-07-01), Hirsch et al.
patent: 4617307 (1986-10-01), Browne
patent: 4728645 (1988-03-01), Browne

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