Pyrido[2,3-d]pyrimidine derivatives

Details Pyrido[2,3-d]pyrimidine derivatives Pyrido[2,3-d]pyrimidine derivatives

1988-02-05

1989-12-26

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544279, A61K 31505, C07D47104

Patent

active

048898597

ABSTRACT:
Derivatives of N-[2-(5,6,7,8-tetrahydropyrido-[2,3-d]pyrimidin-6-yl)-alkyl]benzoyl-L-glut amic acid are antineoplastic agents. A typical embodiment is N-(2-fluoro-4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido-[2,3-d]pyrimi din-6-yl)ethyl]benzoyl)-L-glutamic acid.

REFERENCES:
patent: 4684653 (1987-08-01), Taylor et al.
Merck Index (1983) pp. 599 & 1408.

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