Process for preparing spectinomycin analogs: N-demethylation of

Details Process for preparing spectinomycin analogs: N-demethylation of Process for preparing spectinomycin analogs: N-demethylation of

1983-02-23

1984-07-10

Love, Ethel G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07H 1704, C07H 1700, C07D31924

Patent

active

044594178

ABSTRACT:
This invention is a novel chemical particularly concerned with N-dealkylation of secondary amines as found in amino-cylitols of which spectinomycin is an example. Separation and further alkylation also comprise the present invention process.

REFERENCES:
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patent: 3583972 (1971-06-01), Birkenmeyer et al.
patent: 4264776 (1981-04-01), Hershman et al.
patent: 4351771 (1982-09-01), White et al.
U.S. application Ser. No. 150,530, filed May 16, 1980.
Birkenmeyer et al. "Lincomycin. XIII. N-dealkylation of Lincomycin and its Analogs", Tetrahedron Letters No. 58, pp. 5049-5051, 1970.
Rosenbrook, et al., ACS Symposium Series No. 125, pp. 133-144 (1980).
Borch et al., J. Am. Chem. Soc., 93, pp. 2897-2904 (1971).
R. A. Boissonas, "Selectively Removeable Amino Protective Group Used in the Synthesis of Peptides," Advances in Organic Chemistry, 3:159-190 (1963).
Aldrich Technical Information Bulletin entitled "BOC--ON" (Sep. 1976).
Heyns et al. pp. 210-214, Advances in Carbohydrate Chemistry, 17, (1962).
March, Advanced Organic Chemistry: Reactions, Mechanisms and Structure, p. 875, McGraw-Hill Book Co. (1968).

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