Nephelometric method for determination of an antigen or antibody

Details Nephelometric method for determination of an antigen or antibody Nephelometric method for determination of an antigen or antibody

1986-10-23

1989-12-26

Warden, Robert J.

Chemistry: analytical and immunological testing

Involving kinetic measurement of antigen-antibody reaction

436536, 436805, 436825, 436909, G01N 33536, G01N 33557

Patent

active

048898155

ABSTRACT:
A method and apparatus for use in quantifying, in a whole blood sample in which the red cells are lysed, a component which will react with a reagent to form an antigen-antibody complex, the method comprising mixing the sample with the reagent to obtain the complex, exposing the sample to a source of radiation and measuring the intensity of radiation scattered through a given angle by the complex, and the apparatus including a container for receiving the sample which has been treated with the reagent to the component, the container being transparent to radiation having a wavelength falling within a given band width, typically 460-530 nm. A source of radiation within this band width is provided together with a device for detecting the intensity of radiation scattered through a given angle by the sample.

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IEEE Transactions on Bio-Medical Engineering, vol. BME-17, No. 2, Apr. 1970, pp. 129-133, IEEE, New York, US: C. C. Johnson: "Optical Diffusion in Blood."
Whicher et al., In Butt (Ed.) Practical Immunoassay, Marcel Dekker, Inc., New York, 1984. p. 151.
Whicher et al., In Butt (Ed.), Practical Immunoassay,,Marcel Dekker, Inc., New York, 1984, pp. 143-144.

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