Process for making 3-prenylated menaquinones and ether intermedi

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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260396R, 2604105, 260479R, 260613D, 260613R, C07C 4104, C07C 4516, C07C 4966

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039489582

ABSTRACT:
3-Prenyl-substituted-2-alkyl menaquinones are made by reacting an alkali metal salt of a 3-alkyl-4-alkoxy or aralkoxy-1-naphthol with a prenyl halide, and oxidizing the resulting 2-prenyl-3-alkyl-4-alkoxy or aralkoxy-1-naphthol to the corresponding 3-prenyl-substituted-2-alkyl menaquinone. There is also disclosed a procedure for making the alkali metal salts involving the preparation of an ether-ester and hydrogenolysis.

REFERENCES:
patent: 2235884 (1941-03-01), John et al.
patent: 2348037 (1944-05-01), Thayer et al.
patent: 2376984 (1945-05-01), Tishler
patent: 3896153 (1975-07-01), Sato et al.

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