Process for preparing thieno-fused heterocyclic anti-ulcer agent

Details Process for preparing thieno-fused heterocyclic anti-ulcer agent Process for preparing thieno-fused heterocyclic anti-ulcer agent

1984-09-28

1986-05-06

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548210, 549 60, C07D51304, C07D33334

Patent

active

045873453

ABSTRACT:
A process for preparing certain thieno-fused heterocyclic compounds having H.sub.2 -receptor antagonist and antisecretory activity, which comprises reacting a suitable thienoisothiazole derivative with an appropriate (furanylmethylthio)ethanamine derivative to yield an intermediate, which is subjected to cyclization to yield the desired final product.

REFERENCES:
patent: 4028373 (1977-06-01), Hromatka et al.
patent: 4104388 (1978-08-01), Wade et al.
patent: 4490527 (1984-12-01), Schiehser et al.
Rossy et al., "Aromatization of Dihydrothiophenes . . . ," J. Org. Chem., 45: pp. 617-620 (1980).
Imai et al., "Ring-Opening Polymerization of Ethansultam," Chem. Abst., 82:98451(p) (1974).

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