Method and apparatus for detecting low concentrations of (bio) c

Details Method and apparatus for detecting low concentrations of (bio) c Method and apparatus for detecting low concentrations of (bio) c

1988-04-11

1989-12-26

McGraw, Vincent P.

Optics: measuring and testing

Of light reflection

G01N 2155

Patent

active

048894273

ABSTRACT:
A method and an apparatus for detecting low concentrations of at least one (bio-) chemical component present in a test medium in a test cell, having a metal layer as sub wall with an external glass prism, using the surface plasmon resonance effect. A light ray is coupled in and, after attenuated total reflection, is coupled out and the intensity thereof is measured. The incidence angle position of the resonance curve is determined under the influence of the change, caused by the component, in the dielectric constant of the test medium near the metal layer. An adjustable selector is applied to the metal layer, in order to influence the incidence angle position of the resonance curve, through which the concentrations or concentration changes of one or more components in the test medium can be simultaneously determined through one or more differential measurements. A preferential association and therefor a higher concentration at the metal layer of one component above another is brought about.

REFERENCES:
Gordon et al., "Surface Plasmons as a Probe of the Electrochemical Interface", Surface Science, 101: 499-506 (1980).
Oda et al., "Instantaneous Observation of Angular Scan-Attenuated Total Reflection Spectra", Optics Communications, vol. 59, Nos. 5, 6, pp. 361-365 (Oct. 1986).
Foley et al., "In Situ Infrared Spectroelectrochemistry", Analytical Chemistry, vol. 57, No. 8, pp. 945(A)-956(A) (Jul. 1985).
Ashley et al., "Modulated Surface Vibrational Spectroscopy at the Electrode-Solution Interface", Trends in Analytical Chemistry, vol. 4, No. 6, pp. 142-145 (1985).

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