Polymerized vesicles and compounds for their preparation

Details Polymerized vesicles and compounds for their preparation Polymerized vesicles and compounds for their preparation

1984-06-08

1986-05-06

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

560224, 260546, C11C 100, C07C 5702, C07C 6954

Patent

active

045870551

ABSTRACT:
Lower-.omega.-alkenoyloxy-long chain alkanoic anhydrides are synthesized from the .omega.-hydroxyalkanoic acids and are condensed with glycerophosphatidyl cholines to prepare alkenoyloxyalkanoic esters of glycerophosphatidyl cholines. These are used to make vesicles which are then polymerized in situ. These vesicles show improved stability and the rate of leakage of entrapped active ingredients such as drugs can be controlled. They are also used to form a hydrophyllic monolayer on polyethylene.

REFERENCES:
patent: 2531275 (1950-11-01), Jones
patent: 2599549 (1952-06-01), Fisher et al.
patent: 2689863 (1954-09-01), Broderick et al.
patent: 3326958 (1967-06-01), Curtius et al.
Clark, N. G., Modern Organic Chemistry (1964), Oxford University Press, pp. 216-218.

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