Certain 1,2-benzisoxazole and 1,2-benzisothiazole derivatives

Details Certain 1,2-benzisoxazole and 1,2-benzisothiazole derivatives Certain 1,2-benzisoxazole and 1,2-benzisothiazole derivatives

1989-06-09

1990-09-18

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548207, A61K 31425, C07D11706

Patent

active

049579312

ABSTRACT:
Disclosed are 1,2-benzisoxazole and 1,2-benzisothiazole derivatives represented by formula I ##STR1## wherein X represents oxygen or sulfur; Z represents carbon (CH) so as to complete the imidazol-1-yl ring radical or Z represents nitrogen (N) so as to complete the 1,2,4-triazol-l-yl ring radical; R.sub.1 represents hydrogen, lower alkenyl, lower alkynyl, aryl-lower alkyl or lower alkyl; R.sub.2 represents hydrogen, lower alkenyl, lower alkynyl, aryl-lower alkyl or lower alkyl; or R.sub.1 and R.sub.2 combined represent lower alkylene; or R.sub.1 combined with R.sub.5 located on the Z-carbon atom of the imidazolyl radical represents C.sub.2 -C.sub.4 -alkylene; R.sub.3 and R.sub.4 independently represent hydrogen, lower alkyl, cycloalkyl, halogen, trifluoromethyl, cyano, nitro, amino, hydroxy, lower alkanoyloxy, carbocyclic aroyloxy, lower alkoxy, or carbocyclic aryl; or R.sub.3 and R.sub.4, together when located on adjacent carbon atoms, represent lower alkylenedioxy; or R.sub.3 and R.sub.4, together when located on the carbon atoms to which attached a benzo-fused or C.sub.5 -C.sub.7 -cycloalka-fused ring, respectively; R.sub.5 located on carbon represents hydrogen, lower alkyl or hydroxy-lower alkyl; R.sub.6 located on carbon represents hydrogen or lower alkyl; or when Z represents carbon, R.sub.5 located on the Z-carbon atom combined with R.sub.6 located on the adjacent carbon atom represents C.sub.3 -C.sub.5 -alkylene; and pharmaceutically acceptable salts thereof; which are active in mammals as anticonvulsant agents.

REFERENCES:
patent: 4150153 (1979-04-01), Walker
patent: 4172896 (1979-10-01), Uno et al.
patent: 4206217 (1980-06-01), Hagen et al.
patent: 4275071 (1981-06-01), Nordi et al.
patent: 4598152 (1986-07-01), Davis et al.
patent: 4644064 (1987-02-01), Shutske
patent: 4723021 (1988-02-01), Shiokawa et al.
patent: 4742060 (1988-05-01), Georgiev et al.
patent: 4851424 (1989-07-01), Allgeier
patent: 4859691 (1989-08-01), Bowman
K. Clarke et al., J. Chem. Research (S), 1979, 395:als (M) 4677-4692.
H. Hettler, Chemical Abstracts, 65, 16956d, (1966).
K. Walker et al., J. Med. Chem., 24, 67, (1981).
Uno Hitoshi et al., J. Med. Chem., 22, 180, (1979).
D. Nardi et al., J. Med. Chem., 24, 727, (1981).
M. Giannella et al., Chimie Therapeutique, 1972, 127.
Uno Hitoshi et al., Chem. Pharm. Bull., 24, 632, (1976).
Drugs of the Future, 10, 731, (1985).
D. Robertson et al., J. Med. Chem., 30, 939, (1987).
M. Giannella et al., Phytochemistry, 10, 539, (1971).

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