Process for making optically active alpha-amino ketones and sele

Details Process for making optically active alpha-amino ketones and sele Process for making optically active alpha-amino ketones and sele

1994-04-22

1996-01-30

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 24, 560 32, 560 81, 560115, 560127, 560190, 560193, 562401, 562442, 562444, 562451, C07C22900

Patent

active

054881323

ABSTRACT:
The invention includes selected novel optically active .alpha.-amino ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as antibiotics, antibiotic enhancers, or enzyme inhibitors. Further, the present invention provides a method for dehydrogenation/asymmetrical hydrogenation to obtain essentially pure antipodes of ketomethylene pseudopeptides having two chiral centers.

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