Preparation of oligodeoxyribonucleoside alkyl or arylphosphonate

Details Preparation of oligodeoxyribonucleoside alkyl or arylphosphonate Preparation of oligodeoxyribonucleoside alkyl or arylphosphonate

1984-04-30

1986-05-27

Kight, John

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

536 27, 536 28, 536 29, 514 7, 514 76, C07H 1910, C07H 2102, C07H 2104

Patent

active

045916144

ABSTRACT:
Oligonucleoside-3'-alkyl or aryl phosphonates are prepared by condensing (i) a 5'-protected nucleoside 3'-alkyl or aryl phosphonic imidazolide with (ii) a nucleoside or oligomer which is attached through its 3'-position to a polymer support. The process is advantageously carried out in the presence of tetrazole.

REFERENCES:
patent: 4401796 (1983-08-01), Itakura
patent: 4458066 (1984-07-01), Caruthers et al.

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