Surgery – Controlled release therapeutic device or system – Osmotic or diffusion pumped device or system
Patent
1988-12-13
1990-09-18
Schwadron, Martin P.
Surgery
Controlled release therapeutic device or system
Osmotic or diffusion pumped device or system
604131, 6048911, A61K 924
Patent
active
049574949
ABSTRACT:
A dispenser for use in a fluid environment which is capable of delivery of plurality of discrete drug containing layers in any desired delivery pattern or profile. The dispenser comprises a rigid housing containing a plurality of drug layers which may be separated by drug-free layers. An outlet is provided at one end of the housing and a fluid actuated driving means is provided between the other end of the housing and the drug layers. The portion of the housing in proximity to the driving means has a controlled permeability to water whereby, upon immersion in a fluid environment the drug layers are driven towards the outlet. Various delivery patterns are possible by appropriate selection of the comparison and dimensions of the drug and drug-free layers.
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Using the Alzet Osmotic Pumps to Generate a Circadian Rhythm and Technical Tip, No. 17, May, 1986.
Eckenhoff James B.
Theeuwes Felix
Wong Patrick S.-L.
ALZA Corporation
Flanigan Allen J.
Larson Jacqueline S.
Mandell Edward L.
Sabatine Paul L.
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