Process for the cleavage of cephalosporin prodrug esters to 7-am

Details Process for the cleavage of cephalosporin prodrug esters to 7-am Process for the cleavage of cephalosporin prodrug esters to 7-am

1993-05-19

1995-04-25

Rizzo, Nicholas

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540228, C07D50104

Patent

active

054100429

ABSTRACT:
The present invention relates to a process for the preparation of 7-amino-3-methoxymethylceph-3-em-4-carboxylic acid (I) from 7-amino-3-methoxymethylceph-3-em-4-carboxylic acid esters (II) or their salts by ester cleavage.
The process comprises treating the compound II with formic acid, trifluoroacetic acid, methanesulfonic acid or trifluoromethanesulfonic acid or a mixture of two of these acids in each case.

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