Aminobiphenyl-4-ol anti-atherosclerotic compounds and method

Details Aminobiphenyl-4-ol anti-atherosclerotic compounds and method Aminobiphenyl-4-ol anti-atherosclerotic compounds and method

1994-08-18

1996-01-30

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564307, A61K 31135

Patent

active

054880688

ABSTRACT:
Antiatherosclerotic compounds are provided which have the structure ##STR1## wherein R.sup.1 and R.sup.2 are independently hydrogen, lower alkyl, or arylalkyl, at least one of R.sup.1 and R.sup.2 being other than hydrogen, and R.sup.3, R.sup.4 and R.sup.5 are independently hydrogen, lower alkyl, lower alkenyl, halo, alkoxy, aryl or arylalkyl. A method for treating atherosclerosis employing the above compounds is also provided.

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Bjorkhem, I., et al, "The Antioxidant Butylated Hydroxytoluene Protects Against Atherosclerosis", Arteriosclerosis and Thrombosis, vol. 11, No. 1, Jan./Feb. 1991, pp. 15-22.
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