Piperazine-substituted pyrroloanthracenes

Details Piperazine-substituted pyrroloanthracenes Piperazine-substituted pyrroloanthracenes

1993-12-09

1995-04-25

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544373, 514825, A61K 31495, C07D40300

Patent

active

054099323

ABSTRACT:
The piperazine-substituted pyrroloanthracenes are prepared by reacting either furanoanthracenes with piperazinalkylamines or reacting unsubstituted pyrroloanthracenes first with dihalogenoalkyl compounds and then with appropriately substituted piperazines or by reacting furan derivatives first with piperazinalkylamines and then condensing with anthracenes. The new compounds can be employed as active ingredients in medicaments, in particular in immunomodulators.

REFERENCES:
patent: 4732984 (1988-03-01), Abou-Gharbia et al.
patent: 4804751 (1989-02-01), Abou-Gharbia et al.
Stites et al, Basic and Clinical Immunology 7th Edition, pp. 722 and 784 (1991).
Blue, Daley, Levine, Craig and Schlossmann, "Biosynthesis and Surface Expression of T8 by Peripheral Blood T4+ in Vitro" (1986).
Connolly, Stecher, Speight, Becker and Rathman, "Differential effects of anti-arthritic agents on subnormal plasma iron levels . . . rats" (1989).
Sokoloff, "Animal Models of Rheumatoid Arthritis" International Review of Experimental Pathology, vol. 26 (1984).
Aune, Kelley, Ranges and Bombara, "Serotonin-Activated Signal-Transduction Via Serontonin Receptors and Jurkat Cells" (1990).
Billingham, Butler and Colston, "A Mycobacterial 65-kD Heat Shock Protein Induces Antigen-Specific Suppression . . . " Brief Definitive Report (1990).

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