Oxazobicyclo terminated alkylamino ethynyl alanine amino diol co

Details Oxazobicyclo terminated alkylamino ethynyl alanine amino diol co Oxazobicyclo terminated alkylamino ethynyl alanine amino diol co

1994-01-25

1995-04-25

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544105, A61K 31535, C07D26528

Patent

active

054099250

ABSTRACT:
Compounds characterized generally as oxazobicyclo-terminated alkylamino ethynyl alanine amino diol derivatives hypertension. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 ; wherein X is selected from oxygen atom and methylene; wherein B is an oxazobicyclo group; wherein R.sub.1 is selected from hydrido, methyl, ethyl, isopropyl and n-propyl; wherein R.sub.2 is phenylmethyl; wherein each of R.sub.3 and R.sub.5 is hydrido; wherein R.sub.4 is selected from ##STR2## wherein V is selected from hydrido and methyl; wherein R.sub.6 is cyclohexylmethyl; wherein R.sub.7 is selected from isobutyl, cyclopropyl and cyclopropylmethyl; wherein q is a number selected from zero through three, inclusive; and wherein n is a number selected from zero through three, inclusive; or a pharmaceutically-acceptable salt thereof.

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