Pharmaceutically acceptable salt of 7B-[2-(5-amino-1,2,4-thio-di

Details Pharmaceutically acceptable salt of 7B-[2-(5-amino-1,2,4-thio-di Pharmaceutically acceptable salt of 7B-[2-(5-amino-1,2,4-thio-di

1993-04-02

1995-04-25

Rizzo, Nicholas

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540222, C07D50146, A61K 31545

Patent

active

054099196

ABSTRACT:
A compound of the formula: ##STR1## wherein R.sup.1 is an amino group which may be protected, R.sup.3 is a hydrogen atom or an optionally substituted hydrocarbon residue; Z is S, S.fwdarw.O, O or CH.sub.2, R.sup.4 is a hydrogen atom, methoxy group or formamido group, R.sup.13 is a hydrogen atom, methyl group, hydroxyl group or halogen atom and A.sup..sym. is an optionally substituted imidazolium-1-yl group forming a condensed ring at the 2,3- or 3,4-position or a pharmaceutically acceptable salt or ester thereof is novel and has excellent antibacterial activity.

REFERENCES:
patent: 4665065 (1987-05-01), Miyake et al.
patent: 4788185 (1988-11-01), Miyake et al.
patent: 4826834 (1989-05-01), Yoshimura et al.
patent: 4864022 (1989-09-01), Miyake et al.
patent: 4921851 (1990-05-01), Kishimoto et al.
patent: 4962100 (1990-10-01), Miyake et al.
patent: 4978752 (1990-12-01), Maeda et al.

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