Protease inhibitory polypeptides derived from urinary trypsin in

Details Protease inhibitory polypeptides derived from urinary trypsin in Protease inhibitory polypeptides derived from urinary trypsin in

1991-11-13

1995-04-25

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 435 692, A61K 3764, C07K 710

Patent

active

054098955

ABSTRACT:
This invention provides a novel polypeptide which comprises an amino acid sequence that constitutes a portion of urinary trypsin inhibitor (UTI) and which has no antigenicity against human and high activity to inhibit various proteases, as well as other novel polypeptides having excellent activities to inhibit various proteases obtained by mutation of the former novel polypeptide. This invention also provides novel enzyme inhibition processes, drug compositions and treating methods making use of the novel polypeptide, DNA fragments containing nucleotide sequences which encode the novel polypeptides, vectors containing the DNA fragments and transformants transformed with the DNA fragments or the vectors, as well as processes for the production of the novel polypeptides.

REFERENCES:
patent: 4894436 (1990-01-01), Auerswald et al.
Lau, P. et al.: Proteolytic Degradation of Human Recombinant Proinsulin/Insulin by Sera from Acute Pancreatitis Patients and Complete Inhibition by Eglin C. Pancreas 5:17-26 (1990).
Hochstrasser et al., Hoppe-Seyler's Z. Physiol. Chem. 360: 1285-1296 (1979).
Hirano et al., Digestive Dis. Sci. 38:660-664 (1993).
Lau et al.,; Pancreas 5:17-26 (1990).
Hiroshi Kido et al, "Kunitz-type Protease Inhibitor Found in Rat Mast Cells", The Journal of Biological Chemistry, vol. 263, No. 34, pp. 18104-18107, 1988.
Wallace L. McKeehan et al., The Journal of Biological Chemistry, vol. 261, No. 12 (Apr., 1986), pp. 5378-5383, "Two Apparent Endothelial Cell Growth Factors from Human Hepatoma Cells are Tumor-Associated Proteinase Inhibitors".
Kenji Yoshida et al., Nippon Rinsho, vol. 48, No. 1 (1990), pp. 165-172, "Antienzyme preparations in the treatment of acute pancreatitis".
G. J. Proksch et al., J. Lab. Clin. Med., vol. 79, No. 3 (1972), pp. 491-499, "The purification of the trypsin inhibitor from human pregnancy urine".
Hiroyuki Sumi et al., J. Physiol. Soc. Japan, vol. 39 (1977), pp. 53-58, "Trypsin inhibitors in human urine".
J. Bourguignon et al., Biochemical and Biophysical Research Communications, vol. 131, No. 3 (1985), pp. 1146-1153, "Human Inter-Alpha-Typsin-Inhibitor: Characterization and Partial Nucleotide Sequencing of a Light Chain-Encoding cDNA".
Hiroyuki Sumi et al., Blood & Vessel, vol. 19 (1988), pp. 545-557, "Structure, function and distribution of acid-stable trypsin-plasmin inhibitors (urinary trypsin inhibitor related substances)".
Tadahiro Shikimi, Pharma Medica, vol. 7, No. 11 (1989) pp. 169-174, "Biochemical background of human urinary trypsin inhibitor, urinastatin".
Haruo Ohnishi et al., Folia Pharmacol., Japan, vol. 81 (1983), pp. 235-244, "Therapeutic effects of human urinary trypsin inhibitor on acute experimental pancreatitis".
Karl Hochstrasser et al., Hoppe-Seyler's Z. Physiol. Chem., vol. 364 (1983), pp. 1689-1696, "Kunitz-Type Proteinase Inhibitors Derived by Limited Proteolysis of the Inter-Alpha-Trypsin Inhibitor, VIII.sup.[1-7] ".
Chemical Abstracts 100(15): 117045t, Sumi et al., "Enzymic modification of fibrinolytic and antifibrinolytic components," 1984, p. 246.
Albrecht, et al., "Elastase Inhibition by the Inter-.alpha.-Trypsin Inhibitor and Derived Inhibitors . . . ," Hoppe-Seyler's Z. Physiol. Chem., Bd. 364, Dec. 1983, pp. 1703-1708.
Wachter, et al., "Kunitz-Type Proteinase Inhibitors Derived by Limited Proteolysis . . ." IV[1-3], Hoppe-Seyler's Z. Physiol. Chem., Bd. 362, Oct. 1981, pp. 1351-1355.
Reisinger, et al., "Human Inter-.alpha.-Trypsin Inhibitor: Localization of the Kunitz-Type Domains in the . . . ," Biol. Chemistry Hoppe-Seyler, vol. 366, pp. 479-483 , May 1985.
Kaumeyer, et al., "The mRNA for a proteinase inhibitor related to the HI-30 domain of inter-alpha-trypsin . . . ," Nucleic Acids Research, vol. 14 No. 20, 1986, pp. 7839-7848.
Sakuragawa et al., "Effect of urinastatin on coagulation, fibrinolysis, and platelet, aggregation . . . ," Abstract No. 107:228724c, Chemical Abstracts, vol. 107, 1987, p. 46.
Sakuragawa et al., Saishin Igaku (Current Medicine), vol. 42, 1987, pp. 820-830.
Fukutake et al., Folia pharmacol. Japan, vol. 90, 1987, pp. 163-169.

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