Treatment of erectile dysfunction

Details Treatment of erectile dysfunction Treatment of erectile dysfunction

1994-05-27

1996-01-30

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514634, A61K 3144, A61K 31155

Patent

active

054880599

ABSTRACT:
A method to induce or enhance an erection or treat erectile dysfunction through the administration of a pyridylguanidine compound, preferably, N-cyano-N'(1,1-dimethyl propyl)-N"-3-pyridinyl guanidine, in low doses to the penis. Administration can be by injection into the corpus cavernosum of the penis or transdermal application.

REFERENCES:
patent: 4057636 (1977-11-01), Petersen
patent: 4127118 (1978-11-01), Latorre
patent: 4521421 (1985-06-01), Foreman
patent: 4801587 (1989-01-01), Voss et al.
Holmquist, et al., Effects of Pinacidil on related human Corpus cavernosum penis, Acta Phys Scand 138:463-469 (1990)
Giraldi, et al., Effects of Pinacidil upon penile erectile tissue, in vitro and in vivo, Pharmacology & Toxicology 67:235-238 (1990).
Holmquist, et al., K.sup.+ channel openers for relaxation of isolated penile erectile tissue from rabbit, J Urol 144:146-151 (1990).
FEBS Letters, vol. 287, No. 1, 2, pp. 75-79 (Aug. 1991).

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