Substituted N-cycloalkylmethyl-1H-pyrazolo(3,4-b)quinolin-4 amin

Details Substituted N-cycloalkylmethyl-1H-pyrazolo(3,4-b)quinolin-4 amin Substituted N-cycloalkylmethyl-1H-pyrazolo(3,4-b)quinolin-4 amin

1995-03-10

1996-01-30

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142328, 544126, 546 82, C07D47104, A61K 3147

Patent

active

054880556

ABSTRACT:
Substituted N-cycloalkylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance and d) treating angina pectoris, congestive heart disease and myocardial infarction utilizing them.

REFERENCES:
patent: 4013665 (1977-03-01), Crenshaw et al.
Stein et al, J. Med. Chem. 1970, 13(10), 153-155.
Zikan et al, Chem. Abstracts 108:204613K (1988).
Zikan et al, Chem. Abstracts 106:138447q (1987).
Radl et al, Chem. Abstracts 106:18429P (1987).
Radl et al, Chem. Abstracts 105:226434T (1986).
Crenshaw et al, J. Med. Chem., 1976, 19(2), 262-275.

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