Composition containing a B epitope of the envelope glycoprotein

Details Composition containing a B epitope of the envelope glycoprotein Composition containing a B epitope of the envelope glycoprotein

1993-11-09

1997-11-18

Smith, Lynette F.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530395, 4241881, 4241841, 4242081, 4242041, C07K 100, C07K 1400, A61K 3921, A61K 3912

Patent

active

056889143

ABSTRACT:
Compositions comprise one or more B epitopes of the envelope glycoprotein of a retrovirus and one or more T epitopes of the envelope glycoprotein from a distinct retrovirus, or a T epitope from a different protein of the same retrovirus as the B epitope. In particular, the retrovirus is a human immunodeficiency virus (HIV) or a simian immunodeficiency virus (SIV), human T-cell lymphotropic virus type 1 (HTLVI), or human T-cell lymphotropic virus type II (HTLVII).

REFERENCES:
patent: 5013548 (1991-05-01), Haynes et al.
patent: 5019387 (1991-05-01), Haynes et al.
Bahraoui, et al, 1990, "Immunogenicity of the . . . " AIDS Res. Human Retroviruses.
Chakrabarti, et al, 1987, "Sequence of simian immunodeficiency . . . " Nature 328:543-547.
Goudsmit, et al, 1988, "Human immunodeficiency . . . " PNAS, 85:4478-4482.
Palker, et al, 1989, J. Immunol. 142:3612-3619.
Guy, et al, 1987, Nature 330:266-269.
Culmann, et al, 1989, Eur. J. Immunol. 19:2383-2386.
Guy, et al, 1987, "HIV F/3'ORF encodes a phosphorylated GTP-binding . . . " Nature 330:266-269.
Culmann, et al, 1989, "An antigenic peptide of the HIV-1 NEF Protein . . . " Eur. J. Immunol. 19:2383-2386.
Shoeman et al., "Comparison of Recombinant Human Immunodeficiency Virus gag Precursor and gag/env Fusion Proteins and a Synthetic env Peptide as Diagnostic Regents", Analytical Biochemistry, 161:370-379 (1987).
Ho et al., "Second Conserved Domain of gp120 Is Important for HIV Infectivity and Antibody Neutralization", Science, 239:1021-1023 (1988).
Schrier et al., "B- and T-Lymphocyte Responses to an Immunodominant Epitope of Human Immunodeficiency Virus", Journal of Virology, 62:2531-2356 (1988).
Sternberg et al., "Prediction of Antigenic Determinants and Secondary Structures of the Major AIDS Virus Proteins", FEBS Letters, 218:231-237 (1987).
Zvelebil et al., "Predictions of Liner T-cell and B-cell Epitopes in Proteins Encoded by HIV-1, HIV-2 and SIV.sub.MAC and the Conservation of these Sites Between Strains", FEBS Letters, 242:9-21 (1988).
Putney et al., "HTLV-III/LAV-Neutralizing Antibodies to an E.coli-Produced Fragment of the Virus Envelope", Science, 234:1392-1395 (1986).
Palker et al., "Type-specific Neutralization of the Human Immunodeficiency Virus With Antibodies to env-encoded Synthetic Peptides", Proc. Natl. Acad. Sci. USA, 85:1932-1936 (1988).
Goudsmit et al. "Human Immunodeficiency Virus Type 1 Neutralization Epitope With Conserved Architecture Elicits Early Type-Specific Antibodies in Eperimentally Infected Chimpanzees", Proc. Natl. Acad. Sci. USA, 85:4478-4482 (1988).
Palker et al., "Polyvalent Human Immunodeficiency Virus Synthetic Immunogen Comprised of Envelope gp120 T Helper Cell Sites and B Cell Neutralization Epitopes", Journal of Immunology, 142:3612-3619 (1989).
Guy et al., "HIV F/3' orf encodes a Phosphorylated GTP-binding Protein Resembling an Oncogene Product", Nature, 330:266-269 (1987).
Culmann et al., "An Antigenic Peptide of the HIV-1 NEF Protein Recognized by Cytotoxic T Lymphocytes of Seropositive Individuals in Association With Diffrent HLA-B Molecules", Eur. J. Immunol., 19:2383-2386 (1989).

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