Process for the preparation of 1-carbapenems and intermediates v

Details Process for the preparation of 1-carbapenems and intermediates v Process for the preparation of 1-carbapenems and intermediates v

1981-09-18

1983-05-17

Lee, Mary C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260239A, 424274, 544144, 544316, 544373, 546157, 546272, C07D48704

Patent

active

043839460

ABSTRACT:
Disclosed is a process for the total synthesis of 1-carbapenem antibiotics (I) from L-aspartic acid via central intermediates II and III: ##STR1## wherein R is hydrogen, a pharmaceutically acceptable ester moiety or salt cation, or a readily removable blocking group; R.sup.6, R.sup.7 and R.sup.8 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl; R.sup.1' and R.sup.e are hydrogen, or a readily removable protecting group; R.sup.a, R.sup.b and R.sup.c are selected from alkyl, aryl or aralkyl.

REFERENCES:
patent: 4273709 (1981-06-01), Christensen et al.
patent: 4282148 (1981-08-01), Liu et al.
patent: 4287123 (1981-09-01), Liu et al.

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