Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related a

Details Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related a Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related a

1995-05-31

1997-11-18

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514336, 514343, 546256, 546283, 546284, A61K 3104, C07D40114, C07D40514, C07D40914

Patent

active

056888163

ABSTRACT:
This invention relates to compounds of the formula ##STR1## where R.sub.1 -R.sub.6, X and Y are as defined in the specification, which are useful for the treatment of various memory dysfunctions characterized by a cholinergic deficit and thus may be indicated in the treatment of Alzheimer's disease.

REFERENCES:
patent: 3679692 (1972-07-01), Wu et al.
patent: 3862953 (1975-01-01), Berger et al.
patent: 4699907 (1987-10-01), Gasc
patent: 4880822 (1989-11-01), Effland et al.
patent: 5006537 (1991-04-01), Effland et al.
patent: 5021438 (1991-06-01), Junge et al.
patent: 5039811 (1991-08-01), Effland et al.
patent: 5334597 (1994-08-01), Prasit
Sheinkman et al. "Synthesis and pharmacology of N-(pyridyalkyl)indoline and indoles" CA 70:19857, 1968.
Wilbraham et al. "Organic and biological chemistry" S.III Univ. pp. 268-269, 1985.
Becker et al. "Mechanisms of cholinesterase inhibition in senile dementia of the alzheimer type" Drug.-Develop. Res. v. 12 163-195, 1988.
A.K. Sheinkman, et al.; Chemical Abstracts 70, 19857b (1969).
T. K. Murray, et al., Psychopharmocology 105, 134 (1991), entitled "Reversal by Tetrahydroaminoacridine of Scopolamine-induced Memory and Performance Deficits in Rats", and published in the United States of America.
National Institute of Mental Health Publication No. ADM 90-1696 (1990), entitled "Useful Information on Alzheimer's Disease" and published in the United States of America.
James F. Flood, et al., Brain Research, 215, 177 (1981) entitled "Cholinergic Receptor Interactions and their Effects on Long-Term Memory Processing"; and published in the Netherlands.
James F. Flood, et all, Psychopharmacology, 86, 61 (1985) entitled "Memory Enhancement: Supra-additive Effect of Subcutaneous Cholinergic Drug Combinations in Mice", and published in the United States of America.
Paul E. Gold, Behavioral and Neural Biology, 46, 87 (1986), entitled "The Use of Avoidance Training in Studies of Modulation of Memory Storage" and published in the United States of America.
Paul E. Gold, Animal Learning & Behavior, 17, 94 (1989), entitled "Neurobiological Features Common to Memory Modulation by Many Treatments", and published in the United States of America.

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