Certain pyridyl substituted aminomethyl benzene derivatives havi

Details Certain pyridyl substituted aminomethyl benzene derivatives havi Certain pyridyl substituted aminomethyl benzene derivatives havi

1984-06-04

1987-05-19

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514255, 514227, 514228, 514318, 544 60, 544 82, 544360, 546187, 546281, 546309, 546310, 546312, 546316, 546323, C07D40112, C07D40114, A61K 3144, A61K 31445

Patent

active

046669248

ABSTRACT:
The present invention relates to new compounds of the formula ##STR1## where X is ##STR2## alkylene, or --S--where R.sub.1 is hydrogen, alkyl, or aryl; W is hydrogen, hydroxy, amino, alkyloxy, aryloxy, O-alkyl, or O-aralkyl; (Y).sub.A) is --CH.sub.2 NR.sub.2 R.sub.3 where R.sub.2 and R.sub.3 may be hydrogen, substituted alkyls, aryls, or together with N form a 5 to 7 membered heterocyclic group; and Ar is a substituted or unsubstituted heteroaryl. These compounds are useful in the treatment of various cardiac arrhythmias.

REFERENCES:
patent: 3240781 (1966-03-01), Turner et al.
patent: 4466965 (1984-12-01), Stout et al.
patent: 4562201 (1985-12-01), Stout et al.
Sun et al., ACTA Pharmaceutica Sinica, vol. 16, No. 8, 24 Aug. 1981, pp. 564-570.
Stout et al., J. Med. Chem., 27 (1984), pp. 1347-1350.

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