Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-11-08
1987-05-19
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 80, 546 89, 546 65, 546 92, A61K 3135, C07D491052, C07D51304
Patent
active
046669167
ABSTRACT:
Disclosed are the compounds of the formula ##STR1## wherein X represents oxygen (O) or sulfur (S); ring A is unsubstituted or substituted by one substituent or by two or three identical or different substituents selected from hydroxy, etherified hydroxy, acyloxy, halogen, lower alkyl and trifluoromethyl; or ring A is substituted on adjacent carbon atoms by one lower alkylenedioxy; R represents hydrogen, lower alkyl, aryl-lower alkyl, lower alkenyl, lower alkynyl, aroyl-lower alkyl or aryl-lower alkyl; R.sub.1 represents hydrogen, lower alkyl, lower alkylthio-lower alkyl, aryl-lower alkylthio-lower alkyl, (amino, mono- or di-lower alkylamino)-lower alkyl, acylamino-lower alkyl, (hydroxy, acyloxy or etherified hydroxy)-lower alkyl, or cyano-lower alkyl; R.sub.2 -R.sub.7 represent hydrogen or lower alkyl; and pharmaceutically acceptable salts thereof; which are useful as serotonin-2 receptor antagonists in mammals.
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Ciba-Geigy Corporation
Gruenfeld Norbert
Jiles Henry R.
Richter J.
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