Phenothiazine and derivatives and analogs and use as leukotriene

Details Phenothiazine and derivatives and analogs and use as leukotriene Phenothiazine and derivatives and analogs and use as leukotriene

1986-09-26

1987-05-19

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514236, 514239, 544 35, 544 38, 544 39, 544102, A61K 31535, A61K 3154, C07D26538, C07D27922

Patent

active

046669078

ABSTRACT:
Phenothiazine derivatives and analogs thereof having the Formula I are useful as inhibitors of the biosynthesis of mammalian leukotrienes. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation, and are useful as cytoprotective agents. ##STR1##

REFERENCES:
patent: 3000885 (1961-09-01), Cusic
patent: 3450698 (1969-06-01), Farge et al.
patent: 3471482 (1969-10-01), Sutton
patent: 3591692 (1971-07-01), Sutton
patent: 3961055 (1976-06-01), Baget
patent: 4148885 (1979-04-01), Renoux et al.
Tambi et al., J. Heterocyclic Chem., vol. 20 (1983) pp. 803-805.
Nodiff et al., J. Heterocyclic Chem. vol. 5 (1968) pp. 165-177.
C.A., 77p, 152198Y, 1972.
Collier, Can. J. Med. Sci., 31, 195-201 (1953).
Collier et al., Can. J. Biochem., 43, 105-110 (1965).
Collier et al., Can. J. Biochem. & Phys., 33 773-779 (1955).
Collier et al., Can. J. Res., 20B, 284-290 (1942).
Wightman et al., Biochem J., 197, 523-526 (1981).
Singh et al., Asian Medical J., 19, 60-66 (1976).
Fishman et al., J. Pharm. Exp. Ther., 150, 122-128 (1965).
Bailey et al., Ann. Rpts. Med. Chem., 17, 203-217 (1982).
Bailey et al., Ann. Rpts. Med. Chem. 16, 213-227 (1981).
Baumann et al., Prostaglandins 20, 627-639 (1980).
Sandler, Chap. 16, "Inhibitors of Aarchidonic Acid Metabolism" from Enzyme Inhibitors as Drugs, Univ. Park Press, Baltimore, pp. 249-262.
Mitchell, Drug Met. Rev. 13, 319-343 (1982).
Ellison et al., Am. J. Vet. Res. No. 7, 519-522 (1957).
Rigas et al., Prostaglandins Med., 183-193 (1981).
Perel et al., Neurotoxicology, Raven Press, New York (1977) pp. 9-13.
Halpern, Arch. Int'l Pharm. Ther., 74, 314-333 (1947).
Bhargava et al., Gazz. Chem. Ital., 109, 201-203 (1979).
Garry et al., Biochem. Pharm., 21, 2801-2804 (1972).
Mitchell et al., Drug. Metab. Disp., 7, 399-403 (1979).
Akera et al., Biochem. Pharm., 27, 995-998 (1978).
Creese et al., Eur. J. Pharm., 47, 291-296 (1978).
Schenker et al., Progress in Drug Res., 5, E. Tucker, ed. Birkhauser Verlag, Basel, Switzerland (1963) pp. 269-627.

Affiliated with

Also associated with

Rating

Phenothiazine and derivatives and analogs and use as leukotriene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phenothiazine and derivatives and analogs and use as leukotriene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenothiazine and derivatives and analogs and use as leukotriene will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1565050