Anti-ulcer and anti-hypersecretion dibenzoimidazothiazepine deri

Details Anti-ulcer and anti-hypersecretion dibenzoimidazothiazepine deri Anti-ulcer and anti-hypersecretion dibenzoimidazothiazepine deri

1986-03-12

1987-05-19

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540546, A61K 3138, A61K 3155, C07D51304

Patent

active

046669000

ABSTRACT:
This invention relates to compounds of formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 independently represent hydrogen or a substituent selected from lower alkyl, lower alkoxy, halogen, alkanoyl of 2 to 7 carbon atoms, lower alkoxycarbonyl, halolower alkyl, hydroxy, cyano, amino, mono- or diloweralkyl amino, C.sub.2 -C.sub.7 alkanoylamino, carboxy, carboxylower alkyl, hydroxyloweralkyl, carbamoyl, carbamoyloxy, lower alkyl- or aryl-carbonyl, (lower alkoxy)-lower alkoxy, phenyl or a phenyl group itself optionally substituted by a substituent as hereinbefore defined excepting phenyl, or an adjacent pair of R.sup.1-4 together with the carbon atoms to which they are attached complete a six membered unsaturated carbocyclic or nitrogen containing heterocyclic ring, optionally substituted by one or more of the substituents listed above for R.sup.1 ; m represents 0 or 1; and R.sup.5, R.sup.6, R.sup.7 and R.sup.8 independently represent hydrogen or a substituent selected from lower alkyl, lower alkoxy, halogen, alkanoyloxy of 2 to 7 carbon atoms, lower alkoxycarbonyl and hydroxy and the term `lower` means a group containing 1 to 6 carbon atoms; which compounds possess antisecretory activity and are useful for the treatment of hypersecretion or ulcers.

REFERENCES:
patent: 3932395 (1976-01-01), Hideg et al.
J. Chem. Soc. (C), 1969, 1334-6.
J. Org. Chem., 39(12), 1780-2 (1974).

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