Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...
Patent
1985-01-31
1987-05-19
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing alpha or beta amino acid or substituted amino acid...
435227, 435280, C12N 978, C12P 1304, C12P 4100
Patent
active
046668403
ABSTRACT:
The process of the invention is useful for the preparation of L-.alpha.-aminoacids and is based on the use of an N-carbamyl-.alpha.-aminoacid compound which is contacted with a E.C.3.5.2.2, a dihydropyrimidine hydrolase, enzyme to form a D-hydantoin. The D-hydantoin is hydrolyzed and racemized to form the D-N-carbamyl-.alpha.-aminoacid and the L-N-carbonyl-.alpha.-aminoacid. The L-N-carbamyl-.alpha.-aminoacid is thereafter transformed into the corresponding L-.alpha.-aminoacid.
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Berichte 384, "A. Mouneyrat: Verwandlung der .alpha.Aminosauren in Phenylhydantoine," pp. 2393-2396 (1900).
Wahru, Sun, "Screening of Strains Producing Dihydropyrimidinase and Fermentation Conditions", Weishengwu Xuebao, 1983, 23(3).
Bianchi Giancarlo E.
Centini Felice
Fascetti Eugenio
Olivieri Roberto
Sclavo S.p.A.
Weimar Elizabeth C.
Wiseman Thomas G.
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