Methods and compositions for inhibiting thrombogenesis

Details Methods and compositions for inhibiting thrombogenesis Methods and compositions for inhibiting thrombogenesis

1995-11-13

1997-11-18

Hutzell, Paula K.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

4241301, 4242781, A61K 39395

Patent

active

056885075

ABSTRACT:
Thrombus or clot formation and accretion are inhibited by administering thrombin-displacing substances to a patient. The thrombin-displacing substances comprise either thrombin analogs which bind to the thrombin-binding site on fibrin or fibrin analogs which bind to a fibrin-binding site on thrombin. By displacing the thrombin from clot or thrombus, the thrombin is released into circulation where it is inactivated by endogenous anti-proteinases. The fibrin analogs which bind to the fibrin-binding site on thrombin may be linked to a second binding moiety which binds to and/or inactivates the catalytic site on thrombin to further inhibit thrombosis.

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