Radioactive diagnostic agent

Details Radioactive diagnostic agent Radioactive diagnostic agent

1983-12-05

1987-05-19

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 526315, 536 11, 536 45, 536 51, 536104, 536105, 536126, 525380, A61K 4300, A61K 4900

Patent

active

046666974

ABSTRACT:
A radioactive diagnostic agent which comprises (1) a unit of a polyformyl compound having at least three formyl groups per molecule, (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound a methyleneimine linkage (--CH.dbd.N--) or a methyleneamine linkage (--.sub.2 NH--) formed by the condensation between the formyl group in the polyformyl compound and the amino group in the chelating compound, optionally followed by reduction, (3) at least one unit of an amino group-containing physiologically active substance bonded to the polyformyl compound by a methyleneimine linkage or a methyleneamine linkage formed by the condensation between the formyl group in the polyformyl compound and the amino group in the physiologically active substance, optionally followed by reduction, and (4) at least two radioactive metallic elements of which each is bonded to the chelating compound through a chelating bond.

REFERENCES:
patent: 4046722 (1977-09-01), Rowland
patent: 4385046 (1983-05-01), Milbrath et al.
patent: 4460560 (1984-07-01), Tokes et al.
patent: 4489055 (1984-12-01), Couvreur et al.

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