Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-01-17
1997-07-22
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
A61K 3818, C07K 14475
Patent
active
056504900
ABSTRACT:
The present invention provides for an isolated nucleic acid molecule encoding human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds human TIE-2 ligand. The invention also provides an antibody which specifically binds human TIE-2 ligand. The invention further provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization and a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor.
REFERENCES:
Kozlosky et al. (1995) Oncogene vol. 10, No. 2, pp. 299-306.
Davis Samuel
Jones Pamela F.
Yancopoulos George D.
Cobert Robert J.
Mertz Prema
Regeneron Pharmaceuticals Inc.
Ulm John
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