Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Solid synthetic organic polymer
Patent
1994-03-17
1997-07-22
Kulkosky, Peter F.
Drug, bio-affecting and body treating compositions
Designated organic nonactive ingredient containing other...
Solid synthetic organic polymer
5147726, 514773, 514784, 514785, 514788, 514611, A01N 3326, A61K 4730
Patent
active
056504470
ABSTRACT:
Methods of amelioration, treatment and prevention for restenosis and related disorders are provided. Methods involve the administration of nitric oxide by a nitric oxide delivery means comprising a restenosis-ameliorating or therapeutically/prophylactically effective amount of either a polymer to which is bound a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group a compound comprising a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group. Also provided are nitric oxide delivery means comprising such nitric oxide-releasing polymers or compounds for use in such methods. Preferably, the delivery means is coated with a nitric oxide-releasing polymer, which may be biodegradable, and enables the controllable and predictable release of NO to a given site in such a manner that effective ameliorating, prophylactic or therapeutic dosing is realized.
REFERENCES:
patent: 3880822 (1975-04-01), Perrotti et al.
patent: 4954526 (1990-09-01), Keefer et al.
patent: 5039705 (1991-08-01), Keefer et al.
patent: 5155137 (1992-10-01), Keefer et al.
patent: 5185376 (1993-02-01), Diodati et al.
patent: 5208233 (1993-05-01), Keefer et al.
patent: 5212204 (1993-05-01), Keefer et al.
patent: 5219710 (1993-06-01), Horn et al.
patent: 5250550 (1993-10-01), Keefer et al.
Abrams, "Mechanisms of Action of the Organic Nitrates in the Treatment of Myocardial Ischemia," Amer. J. Cardiology, 70:30B-41B (1992).
Clowes et al., "Kinetics of Cellular Proliferation After Arterial Injury," Lab. Invest., 49(3):327-333 (1983).
Clowes et al., "Mechanisms of Stenosis After Arterial Injury," Lab. Invest., 49(2):208-215 (1983).
Diodati et al., "Complexes of Nitric Oxide with Nucleophiles as Agents for the Controlled Biological Release of Nitric Oxide: Antiplatelet Effect," Thrombosis and Haemostasis, 70(4):654-658 (1993).
Diodati et al., "Complexes of Nitric with Nucleophiles as Agents for the Controlled Biological Release of Nitric Oxide: Hemodynamic Effect in the Rabbit," J. Cardiovasc. Pharmacol., 22:287-292 (1993).
Feldman et al., "The Suprising Life of Nitric Oxide," C&EN:26-38 (Dec. 20, 1993).
Ferns et al., "Inhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF," Science, 253:1129-1132 (1991).
Forrester et al., "A Paradigm for Restenosis Based on Cell Biology: Clues for the Development of New Preventive Therapies," JACC, 17(3):758-769 (1991).
Golino et al., "Endothelium-Derived Relaxing Factor Modulates Platelet Aggregation in an In Vivo Model of Recurrent Platelet Activation," Circ. Res., 71(6):1447-1456 (1992).
Groves et al., "Exogenous Nitric Oxide Inhibits In Vivo Platelet Adhesion Following Balloon Angioplasty," Cradiovasc. Res., 26:615-619 (1992).
Groves et al., "SIN-1 Reduces Platelet Adhesion and Platelet Thrombus Formation in a Porcine Model of Balloon Angioplasty," Circ., 87(2):590-597 (1993).
Hadoke et al., "Characterization of the Responses of Isolated Rings of Rabbit Left Carotid Artery, A Potential Protocol for the Assessment of Pathologically Induced Functional Changes," JPM, 29(4):195-202 (1993).
Harrison, "Endothelial Modulation of Vascular Tone: Relevance to Coronary Angioplasty and Restenosis," JACC, 17(6):71B-76B (1991).
Ip et al., "The Role of Platelets, Thrombin and Hyperplasia in Resenosis After Coronary Angioplasty," JACC, 17(6):77B-88B (1991).
Just et al., "Effect of Molsidomine on Thrombus Formation in Stenosed Coronary Arteries of Dogs and Pigs," J. Cardiovasc. Pharmacol., 14(Suppl. 11):S129-S136 (1989).
Lindner et al., "Proliferation of Smooth Muscle Cells After Vascular Injury is Inhibited by an Antibody Against Basic Fibroblast Growth Factor," PNAS USA, 88:3739-3743 (1991).
Liu et al., "Restenosis After Coronary Angioplasty, Potential Biologic Determinants and Role of Intimal Hyperplasia," Circulation, 79(6):1374-1387 (1989).
McNamara et al., "L-Arginine Inhibits Balloon Catheter-Induced Intimal Hyperplasia," Biochem. and Biophys. Res. Comm., 193(1):291-296 (1993).
Ovize et al., "Inhibition of Coronary Artery Thrombosis by SIN-1, a Donor of Nitric Oxide," J. Cardiovasc. Pharmacol., 16:641-645 (1990).
Reden, J., "Molsidomine," Blood Vessels, 27:282-294 (1990).
Schwartz et al., "The Restenosis Paradigm Revisited: An Alternative Proposal for Cellular Mechanisms," JACC, 20(5):1284-1293 (1992).
Search Report--Bibliographic Citation List Generated by Medlars II regarding Molsidomine.
Search Report--Bibliographic Citation List Generated by Medlars II regarding Linsidomine.
Search Report--Bibliographic Citation List Generated by Medlars II regarding Faxon D.
Search Report regarding Molsidomine or Linsidomine.
Search Report regarding Restensosis or Angioplasty and Nitric Oxide or Nitric Oxide-Releasing Compound.
Article--Nitric-Oxide Boosters May Fight Off PTCA Restenosis.
Mascarenhas Dissertation Abstracts pp. 54-94 Dec. 1993.
Abstract of Soviet Union 537599 Nov. 1977.
Hutsell Thomas C.
Keefer Larry K.
Comedicus Incorporated
Kulkosky Peter F.
The United States of America as represented by the Secretary of
LandOfFree
Nitric oxide-releasing polymers to treat restenosis and related does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nitric oxide-releasing polymers to treat restenosis and related , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nitric oxide-releasing polymers to treat restenosis and related will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1560427