HIV protease inhibitors useful for the treatment of AIDS

Details HIV protease inhibitors useful for the treatment of AIDS HIV protease inhibitors useful for the treatment of AIDS

1995-10-26

1997-07-22

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544362, 544363, 544373, 544374, 544376, 544377, 544387, 544388, 546114, 546115, 549 62, 549517, 549527, 549552, 514 43, 514 49, 514220, 5142305, 514252, A61K 31495, C07D40914

Patent

active

056504128

ABSTRACT:
Compounds of formula ##STR1## are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

REFERENCES:
Bigge, et al., "New Preparations of the N-Methyl-D-Aspartate Receptor Antagonist, 4-(3-phosphonopropyl)-2-. . . ", Tet. Lett., vol. 30, No. 39, pp. 5193-5196, 1989.
Caron, et al., "Radioselective Azide Opening of 2,3-Epoxy Alcohols by [Ti(O-i-Pr)2(N3)2]: Synthesis . . . ", J. Org., Chem., 53, pp. 5185-5187, 1988.
Cohen, et al., "Characterization of the Binding Site for Nevirapine (BI-RG-587), a Nonnucleoside Inhibitor . . . ", J. Biol. Chem., vol. 266, No. 22, pp. 14670-14674, 1991.
Felder, et al., "Uber die Katalytische Hydrierung Von Pyrazincarbonsauren", Helv. Chim. Acta, 43(117), pp. 888-896, 1960.
Gao, et al., "Catalytic Asymmetric Epoxidation and Kinetic Resolution: Modified Procedures Including in Situ Derivatization", J. Am. Chen. Soc., 109, pp. 5765-5780, 1987.
Hargrave, et al., "Novel Non-Nucleoside InhibitorsIV-1 Reverse Transcriptase. 1. Tricyclic Pyridobenzo-- and Dipyridodiazepinones", J. Med. Chem., vol. 34, pp. 2231-2241, 1991.
Klunder, et al., "Novel Non-Nucleotide Inhibitors of HIV-1 Reverse Transcriptase. 2. Tricyclic Pyridobenzoxazapinones and Dibenzaxazapinones", J. Chem., vol.34, pp. 2231-2241, 1991.
Winslow et al, AIDS, 8 pp. 753-756 (1994).
Kageyama et al, Antimicrobial Agents and Chemotherapy 36, pp. 926-933 (1992).

Affiliated with

Also associated with

Rating

HIV protease inhibitors useful for the treatment of AIDS does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with HIV protease inhibitors useful for the treatment of AIDS, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and HIV protease inhibitors useful for the treatment of AIDS will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1560120