Preparation of 2-(pyridinyl)-4-pyrimidinamines

Details Preparation of 2-(pyridinyl)-4-pyrimidinamines Preparation of 2-(pyridinyl)-4-pyrimidinamines

1976-10-07

1978-08-22

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D40104

Patent

active

041090926

ABSTRACT:
The process of reacting a PY-carboxamidine with .alpha.-chloroacrylonitrile in the presence of an acid-acceptor to produce 2-PY-4-pyrimidinamines where PY is 4- or 3- or 2-pyridinyl or 4- or 3- or 2-pyridinyl having one or two lower-alkyl substituents. The products produced by the process are useful as anti-allergic agents per se and, also, are useful as intermediates in the preparation of other anti-allergic agents, namely, dialkyl N-(2-PY-4-pyrimidinyl)-aminomethylenemalonates and analogs, as well as N-(2-PY-4-pyrimidinyl)ureas.

REFERENCES:
tsurushima, "Chemical Abstracts", vol. 74, 1971, col. 13174n.
"Chemical Abstracts", vol. 72, 1970, col. 90504f.

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