Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1978-05-05
1979-06-26
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424250, 424249, 544182, 544212, 544295, 544357, 544363, A61K 31505, C07D40100
Patent
active
041593316
ABSTRACT:
Antihypertensive compounds for the treatment of hypertensive mammals, including man, of the formula III: ##STR1## wherein X is chloro or trifluoromethyl; wherein R is a radical such as triazinyl, pyrazinyl, pyridinyl, pyrimidinyl, phenyl, or the above radicals substituted by one or two trifluoromethyl, halo, alkyl, alkoxy, dialkylamino or alkylthio groups; or R is the group ##STR2## in which R.sub.1 is phenyl, phenyl substituted with one or two halo atoms, alkoxy or alkyl groups, trifluoromethyl, or R.sub.1 is alkylphenylsulfonyl; or R is the group --SO.sub.2 R.sub.2, in which R.sub.2 is dialkylamino, phenyl, phenyl substituted with halo atoms, alkyl, or alkoxy groups, or trifluoromethyl are prepared from (7-chloro)- or (7-trifluoromethyl)-4-chloroquinoline or 1-[[4-[[(7-chloro)- or (7-trifluoromethyl)quinolinyl]amino]phenyl]sulfonyl]piperazine.
REFERENCES:
patent: 3362956 (1968-01-01), Archer
patent: 3992382 (1976-11-01), Coverdale et al.
Armitage Robert A.
Berneis Hans L.
Coughlan, Jr. Paul M.
The Upjohn Company
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