Process for preparing cyano-enol ethers

Details Process for preparing cyano-enol ethers Process for preparing cyano-enol ethers

1977-02-18

1978-08-22

Torrence, Dolph H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424251, C07C12175

Patent

active

041088883

ABSTRACT:
The present invention relates to a new synthesis for the preparation of 5-(substituted benzyl)-2,4-diamino-pyrimidines, including new pyrimidine derivatives. More particularly, a new synthesis of ormetoprin, diaveridine and related compounds, including novel derivatives, is disclosed. The synthesis involves the condensation of a substituted benzene and an acrylonitrile derivative to directly give enol ether intermediates, which upon subsequent reaction by known techniques with guanidine, provides the desired 5-(substituted benzyl)-2,4-diamino-pyrimidines, including novel compounds. The pyrimidine end products are useful as potentiators of sulfonamides and as antibacterial agents.

REFERENCES:
patent: 3049544 (1962-08-01), Stenbuck et al.
patent: 3341541 (1967-09-01), Hoffer
patent: 3697512 (1972-10-01), Cresswell et al.

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