Process for the preparation of 4,6-dichloropyrimidines

Details Process for the preparation of 4,6-dichloropyrimidines Process for the preparation of 4,6-dichloropyrimidines

1996-08-19

1997-10-14

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23930

Patent

active

056774532

ABSTRACT:
4,6-Dichloropyrimidines are obtained by the reaction of 4,6-dihydroxypyrimidines with excess phosphoryl chloride in a particularly advantageous manner when no base is added, during and/or after the reaction 0.75 to 1.5 mol of phosphorus trichloride and 0.7 to 1.3 mol of chlorine are added per equivalent of exchanged hydroxyl groups so that an excess of phosphorus trichloride with respect to chlorine is always present, and finally phosphorus trichloride and phosphoryl chloride are separated off. This process can be carried out in a particularly simple manner and also continuously.

REFERENCES:
Hennart et al., Contribution a la synthesis de la dichloro-4-6 pyrimidine--Societe Chimique de France No. 140, (1959) pp. 741-742.
R. Hull, A New Sythesis of 4:6-dihydroxypyrimidines--J. Chem. Soc. (1951) p. 2214.
Contribution a la synthese de la dichloro-4-6 pyrimidine, Hennart et al., Bull. de la Soc. Chim. France, (1959) pp. 741-742.
Experiments on the Synthesis of Purine Nucleosides. Part IV. . . . , Kenner et al., J. Chem. Soc. (1943), pp. 574-575.
A New Synthesis of 4:6-Dihydroxpyrimidines, Hull, J. Chem. Soc. (1951), p. 2214.
Synthesis of 4-(p-Aminobenzenesulfonamido)-6-Methoxypyrimidine, Zasosov et al., Translated from Khimiko-Farmatsevticheskii Zhurnal, vol. 8, No. 12, pp. 28-31, Dec., 1974. Original article submitted Dec. 6, 1973.

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