Heteroatomic oligonucleoside linkages

Details Heteroatomic oligonucleoside linkages Heteroatomic oligonucleoside linkages

1995-02-23

1997-10-14

Elliott, George C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 243, 536 245, C07H 2100, C07H 2102, C07H 2104

Patent

active

056774370

ABSTRACT:
Oligonucleotide-mimicking macromolecules that have improved nuclease resistance are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligonucleotides with four atom linking groups provide unique compounds that are useful in regulating RNA expression and in therapeutics. Methods of synthesis and use also are disclosed.

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