Treating urinary incontinence using (S)-desethyloxybutynin

Details Treating urinary incontinence using (S)-desethyloxybutynin Treating urinary incontinence using (S)-desethyloxybutynin

1995-06-07

1997-10-14

Rollins, John W.

Abrasive tool making process, material, or composition

With carbohydrate or reaction product thereof

514310, 514946, 424449, 424451, 424464, A61K 31165, A61K 970

Patent

active

056773463

ABSTRACT:
A method for treating urinary incontinence while avoiding concomitant liability of adverse effects associated with racemic oxybutynin is disclosed. The method comprises administering a therapeutically effective amount of (S)-oxybutynin, (S)-desethyloxybutynin or a pharmaceutically acceptable salt thereof, substantially free of the corresponding R enantiomer. Pharmaceutical compositions in the form of tablets and transdermal devices comprising (S)-oxybutynin or (S)-desethyloxybutynin and an acceptable carrier are also disclosed, as is a synthesis of desethyloxybutynin.

REFERENCES:
Lindeke et al. "Metabolism of Oxybutnin: Establishment of Desethyloxybutynin and Oxybutynin N-Oxide Formation in Rat Liver Preparations Using Deuterium Substitution and Gas Chromatographic Mass Spectrometric Analysis" Biomedical Mass Spectrometry, vol. 8, No. 10, 506-513 (1981).
Kasama et al. "Preparation of Substituted Glycolic acid 4-alkyl=amino-2-butynyl Esters as Antispasmodics and for Regulation of Urination" Chemical Abstracts, vol 113:23118k, 586 (1990).
Lish et al. "Oxybutynin--A Musculotropic Antispamodic Drug . . . " Arch. int. Pharmacodyn. 156, 456-488 (1965).
Hock "Clinical Evalution of Oxybutynin Chloride" Current Therpapeutic Research 9, 437-440 (1967).
Fredericks et al. "A Study of the Anticholinergic and Antispasmodic Activity of Oxybutynin . . . " Investigative Urology 12, 317-319 (1975).
Nilvebrant et al. "Dicyclomine, Benzhexol and Oxybutynine Distinguish . . . " Europ. J. Pharmacol. 123, 133-143 (1986).
Tonini et al. "Depressant action of oxybutynin on the contractility . . . " J. Pharm. Pharmacol. 39, 103-107 (1986).
Kachur et al. "R and S Enantiomers of Oxybutynin: Pharmacological Effects . . . " J. Pharm. Exper. Ther. 247, 867-872 (1988).
Noronha-Blob et al. "Muscarinic Receptors: Relationships Among Phosphoinositide . . . " J. Pharm. Exper. Ther. 249, 843-851 (1989).
Noronha-Blob et al. "The Anticholinergic Activity of Agents Indicated for Urinary . . . " J. Pharm. Exper. Ther. 251, 586-593 (1989).
Peterson et al. "In Vivo Cystometrogram Studies in Urethane-Anesthetized and Conscious Guinea Pigs" J. Pharm. Methods 21, 231-241 (1989).
Guarneri et al. "Effects of Oxybutynin, Terodiline, and Nifedipine . . . " Pharm. Research. 24, 263-272 (1991).
Noronha-Blob et al. "Enantiomers of Oxybutynin: In Vitro Pharmacological Characterization . . . " J. Pharm. Exp. Ther . 256, 562-567 (1990).
Lowe et al. "Effect of extracellular Ca.sup.2+ on cholinergic, KCL and phorbol ester-mediated . . . " Eur. J. Pharm. 195, 237-279 (1991).
Massad et al. "The Pharmacokinetics of Intravesical and Oral Oxybutynin Chloride" J. Urology 148, 595-597 (1992).
Angelico et al. "In Vivo Effects of Different Antispasmodic Drugs on the Rat Bladder Contractions" J. Pharm. Methods 27, 33-39 (1992).
Guarneri et al. "Effects of Drugs Used in the Therapy of Detrusor Hyperactivity. . . " Pharm. Research 27, 173-187 (1993).
Hughes et al. "Measurement of oxybutynin and its N-desethyl metabolite in plasma, and . . . " Xenobiotica 22, 859-869 (1992).
Take et al. "Agents for the Treatment of Overactive Detrusor, III. Synthesis and . . . " Chem. Pharm. Bull. 40, 1415-1423 (1992).
Cooley & Evain "Amine Dealkylations with Acyl Chlorides" Synthesis 1989, 1-7 (1989).

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