Phenoxy acetic acids as aldose reductase inhibitors and antihype

Details Phenoxy acetic acids as aldose reductase inhibitors and antihype Phenoxy acetic acids as aldose reductase inhibitors and antihype

1996-08-21

1997-10-14

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

562462, A61K 3119

Patent

active

056773420

ABSTRACT:
This invention relates to 4-formyl-2-(naphthalenylmethyl)phenoxyacetic acids and pharmaceutically acceptable salts thereof according to formula I below, pharmaceutical compositions thereof, a method of treating hyperglycemia due to non-insulin dependent diabetes mellitus, and a method of prevention or treatment of complications associated with diabetes. ##STR1## wherein the group A is selected from the group consisting of 1-naphthyl, 2-naphthyl, optionally substituted with alkyl of from one to six carbon atoms, fluorine, chlorine, bromine, iodine, trifluoromethyl, alkoxy of from one to six carbon atoms; R.sup.1 is hydrogen or alkyl of from one to six carbon atoms; R.sup.2 is selected from hydrogen, fluorine, chlorine, bromine, iodine, alkyl of from one to six carbon atoms, alkoxy of from one to six carbon atoms, and hydroxyl; or a pharmaceutically acceptable metal salt thereof.

REFERENCES:
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patent: 5399588 (1995-03-01), Malamas
patent: 5552441 (1996-09-01), Dillard et al.
Pazur et al., J. Chem. Soc., 1957, pp. 625-628.
Chen and Joullie, Tetrahetron Letters 23(44), pp. 4567-4568, 1982.

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