Emulsion suitable for administering a sphingolipid

Details Emulsion suitable for administering a sphingolipid Emulsion suitable for administering a sphingolipid

1996-07-16

1997-10-14

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514560, 514937, 514669, A61K 3120, A61K 3113

Patent

active

056773412

ABSTRACT:
An acidic emulsion comprising a lipoid dispersed in an aqueous phase, a cationic sphingolipid, and a stabilizing amount of non-ionic surfactant and cholesterol is provided, along with the method of administering the emulsion.

REFERENCES:
patent: H1168 (1993-04-01), McKenna et al.
patent: Re32393 (1987-04-01), Wretlind et al.
patent: 4280996 (1981-07-01), Okamoto et al.
patent: 4757053 (1988-07-01), della Valle et al.
patent: 4816450 (1989-03-01), Beil et al.
patent: 4897381 (1990-01-01), della Valle et al.
patent: 4937232 (1990-06-01), Bell et al.
patent: 5149794 (1992-09-01), Yatvin et al.
patent: 5149860 (1992-09-01), Zysman et al.
patent: 5198470 (1993-03-01), Zysman et al.
patent: 5364632 (1994-11-01), Benita et al.
CA 114:177998, Borek et al., 1991.
CA 119:423, Schwartz et al., 1993.
CA 109:224251, Gupta et al., 1988.
CA 120:208600, McKenna et al., 1993.
McFadyen, Electrophoretic mobility and zeta potential of colloidal particles, American Laboratory, Apr., 1987, pp. 64-75.
Lehninger, The Molecular Basis of Cell Structure and Function, Biochemistry, Second Edition, Chapter 11, Lipids, lipoprotein, and membranes, Worth Publishers, Inc., pp. 291-292 (1975).
Becher, Emulsions: Theory and Practice, Second Edition, American Chemical Society, Monograph Series, Robert E. Krieger Publishing Company, New York, 1977, pp. 1-2; 118-132.
Emulsions in Pharmacy, Remington's Pharmaceutical Sciences, Chapter 19, 18th Edition, 1990, pp. 298-309.
Becher, Encyclopedia of Emulsion Technology, vol. 1, Basic Theory, Marcel Dekker, Inc., New York, pp. 152-159 (1983).
Hannun et al., Regulation of protein kinase C by sphingosine and lysosphingolipids, Clinica Chimica Acta., vol. 185, 1989, pp. 333-346.
Merrill, Jr., et al., Modulation of protein kinase C and diverse cell functions by sphingosine -a pharmacologically interesting compound linking sphingolipids and signal transduction, Biochimica et Biophysica Acta., vol. 1010, 1989, pp. 131-139.
Michell et al., Sphingolipid signalling, Second Messengers, Current Biology, vol. 4, No. 4, 1994, pp. 370-374.
Sweeley, Sphingolipids, Chapter 11, D.E. Vance and J. Vance (Eds.) Biochemistry of Lipids, Lipoproteins and Membranes, 1991, pp. 327-361.
Hannun et al., Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids, Biochimica et Biophysica Acta., vol. 1154, 1993, pp. 223-236.
Franson et al., Sphingolipid metabolism and signal transduction: inhibition of in vitro phospholipase activity by sphingosine, Biochimica et Biophysica Acta., vol. 1136, 1992, pp. 169-174.
Srivastava et al., Liquid Membrane Phenomena and Drug Action, Advances in Colloid and Interface Science, vol. 20 (1984), pp. 131-161.
Burke, Sphingosomes in Skincase, Manufacturing Chemist, Jul., 1990, pp. 36-37.
Imokawa et al., Importance of intercellular lipids in water-retention properties of the stratum corneum: induction and recovery study of surfactant dry skin, Arch. Dermatol. Res. (1989) vol. 281, pp. 45-51.
CA 119: 27 8770; Benita et al., 1993.
Remington's Pharmaceutical Sciences, 18th Ed., 1990, pp. 300-303.
Scaro et al., Experientia, vol. 38, No. 3, 1982, pp. 401-403.

Affiliated with

Also associated with

Rating

Emulsion suitable for administering a sphingolipid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Emulsion suitable for administering a sphingolipid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Emulsion suitable for administering a sphingolipid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1555821