Bicyclic .beta.-lactams intermediates having a new amino protect

Details Bicyclic .beta.-lactams intermediates having a new amino protect Bicyclic .beta.-lactams intermediates having a new amino protect

1994-09-21

1995-09-26

Rizzo, Nicholas

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540215, 540228, 540230, C07D50120

Patent

active

054535042

ABSTRACT:
A method for preparing a new class of protected amino intermediates is provided which utilizes reaction of an imido protected primary amine with a secondary amine. The intermediates thus provided are suitably protected for nucleophilic functionalization on the residue of the primary amine. The desired imido protected amine thus derivatized may be regenerated using acid. Further provided are methods for resolving racemic primary amines. Also provided are .beta.-lactam intermediates protected with the new amino protecting group which are useful in the preparation of .beta.-lactam antibiotics.

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