Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1994-05-02
1995-09-26
Jordan, Kimberly R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
424 45, 514653, 222635, A61K 3116, A61K 31135, A61L 904
Patent
active
054534453
ABSTRACT:
An aerosol-dispensable pharmaceutical composition consisting essentially of a combination of lidocaine free base, a pharmacologically-acceptable phenylephrine acid addition salt, and a pharmacologically-acceptable organic solvent, all dissolved in a propellant selected from the group consisting of 1,1,1,2-tetrafluoroethane of the formula CF.sub.3 CH.sub.2 F (HFC-134a) and 1,1,1,2,3,3,3-heptafluoropropane of the formula CF.sub.3 CHFCF.sub.3 (HFC-227) or a combination of the said propellants, suitable for dispensing by means of a metered-dosage valve canister in which it is contained under pressure, avoids the necessity of premixing individual solutions by the physician just prior to use. The phenylephrine salt is preferably the hydrochloride and the solvent is preferably ethanol although other pharmacologically-acceptable solvents and pharmacologically-acceptable acid addition salts of phenylephrine may be employed. The lidocaine free base assists in solubilizing the phenylephrine salt and maintaining it in solution in the propellant.
REFERENCES:
CA 105: 197096b, Omray, Jul. 1986.
The Merck Index, 11th ed., Dec. 1989, No. 7257, phenyl-ephrine hydrocholoride.
Remington's Pharmaceutical Sciences, 18th ed., Sep. 1990, p. 1706.
Jeffrey Gross et al., Anesthesia & Analgesia 63: 915-918 (Feb. 1984).
Curtis N. Sessler et al., Anesthesiology 64: 274-277 (Jul. 1986).
Robert M. Middleton et al., Chest 99:5 1093-1096 (Oct. 1991).
CPS 25th Edition 1991 (Compendium of Pharmaceuticals and Specialties, Canadian Pharmaceutical Society), p. 406.
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