Bis(aryloxy)alkanes as inhibitors of phospholipase A.sub.2 enzym

Details Bis(aryloxy)alkanes as inhibitors of phospholipase A.sub.2 enzym Bis(aryloxy)alkanes as inhibitors of phospholipase A.sub.2 enzym

1994-07-20

1995-09-26

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514571, 514533, 514534, 514545, 560 11, 560 15, 560 60, 562429, 562431, 562459, 562463, 562470, 562472, A61K 3119

Patent

active

054534437

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of the PLA.sub.2 s enzymes. These compounds are useful as anti-allergic, anti-asthmatic, they are also useful in treating various inflammatory diseases such as rheumatoid arthritis, osteoarthritis, bursitis, psoriasis; immunoinflammatory disorders such as contact dermatitis, irritable bowel disease and the like.

REFERENCES:
patent: 4820867 (1989-04-01), Belanger et al.
patent: 5135940 (1992-08-01), Belanger et al.

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